Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels

MF Keating; C Yang; Y Liu; EA Gould; MT Hallam; DC Henstridge; NA Mellett; PJ Meikle; KI Watt; P Gregorevic; AC Calkin; BG Drew

Journal article

Hepatic retinol dehydrogenase 11 dampens stress associated with the maintenance of cellular cholesterol levels

MF Keating, C Yang, Y Liu, EA Gould, MT Hallam, DC Henstridge, NA Mellett, PJ Meikle, KI Watt, P Gregorevic, AC Calkin, BG Drew

Molecular Metabolism | ELSEVIER | Published : 2024

DOI: 10.1016/j.molmet.2024.102041

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Abstract

Objective: Dysregulation of hepatic cholesterol metabolism can contribute to elevated circulating cholesterol levels, which is a significant risk factor for cardiovascular disease. Cholesterol homeostasis in mammalian cells is tightly regulated by an integrated network of transcriptional and post-transcriptional signalling pathways. Whilst prior studies have identified many of the central regulators of these pathways, the extended supporting networks remain to be fully elucidated. Methods: Here, we leveraged an integrated discovery platform, combining multi-omics data from 107 strains of mice to investigate these supporting networks. We identified retinol dehydrogenase 11 (RDH11; also known ..

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University of Melbourne Researchers

Peter Meikle Author

Kevin Watt Author

Paul Gregorevic Author

Brian Drew Author

Related Projects (1)

USING GENE DELIVERY TECHNOLOGIES TO DEFINE NOVEL MECHANISMS OF SKELETAL MUSCLE ADAPTATION, AND DEVELOP MUSCLE-DIRECTED INTERVENTIONS FOR FRAILTY AND SERIOUS ILLNESS

The focus of my research is to investigate the cellular mechanisms underlying regulation of skeletal muscle size and function in health and ..

Grants

Awarded by State Government of Victoria

Funding Acknowledgements

The Authors thank Dr Hongwei Qian (University of Melbourne) for producing the AAV vectors. This work was supported in part by the Victorian Government's Operational Infrastructure Support Program. PG was supported by funding from the National Health and Medical Research Council of Australia (1117835; 2017070) . ACC was sup-ported by a National Heart Foundation of Australia Future Leader Fellowship (105631) .